Tests of Statistical Significance and Background Estimation in Gamma Ray Air Shower Experiments

In this paper we discuss several methods of significance calculation and point out the limits of their applicability. We then introduce a self consistent scheme for source detection and discuss some of its properties. The method allows incorporating background anisotropies by vetoing existing small scale regions on the sky and compensating for known large scale anisotropies. By giving an example using Milagro gamma ray observatory we demonstrate how the method can be employed to relax the detector stability assumption. Two practical implementations of the method are discussed. The method is universal and can be used with any large field-of-view detector, where the object of investigation, steady or transient, point or extended, traverses its field of view.Comment: 12 pages, 7 figures. Submitted to ApJ, submission number: 5833

Clinical applications of ultra-high field magnetic resonance imaging in multiple sclerosis

Introduction: Magnetic resonance imaging (MRI) is of paramount importance for the early diagnosis of multiple sclerosis (MS) and MRI findings are part of the MS diagnostic criteria. There is a growing interest in the use of ultra-high-field strength 127 Tesla- (7T) MRI to investigate, in vivo, the pathological substrate of the disease. Areas covered: An overview of 7T MRI applications in MS focusing on increased sensitivity for lesion detection, specificity of the central vein sign and better understanding of MS pathophysiology. Implications for disease diagnosis, monitoring and treatment planning are discussed. Expert commentary: 7T MRI provides increased signal-to-noise and contrast-to-noise-ratio that allow higher spatial resolution and better detection of anatomical and pathological features. The high spatial resolution reachable at 7T has been a game changer for neuroimaging applications not only in MS but also in epilepsy, brain tumors, dementia, and neuro-psychiatric disorders. Furthermore, the first 7T device has recently been cleared for clinical use by the food and drug administration

Laminar analysis of the cortical T1/T2-weighted ratio at 7T

Objective: In this observational study, we explored cortical structure as function of cortical depth through a laminar analysis of the T1/T2-weighted (T1w/T2w) ratio, which has been related to dendrite density in ex vivo brain tissue specimens of patients with MS. Methods: In 39 patients (22 relapsing-remitting, 13 female, age 41.1 ± 10.6 years; 17 progressive, 11 female, age 54.1 ± 9.9 years) and 21 healthy controls (8 female, , age 41.6 ± 10.6 years), we performed a voxel-wise analysis of T1w/T2w ratio maps from high-resolution 7T images from the subpial surface to the gray matter/white matter boundary. Six layers were sampled to ensure accuracy based on mean cortical thickness and image resolution. Results: At the voxel-wise comparison (p < 0.05, family wise error rate corrected), the whole MS group showed lower T1w/T2w ratio values than controls, both when considering the entire cortex and each individual layer, with peaks occurring in the fusiform, temporo-occipital, and superior and middle frontal cortex. In relapsing-remitting patients, differences in the T1w/T2w ratio were only identified in the subpial layer, with the peak occurring in the fusiform cortex, whereas results obtained in progressive patients mirrored the widespread damage found in the whole group. Conclusions: Laminar analysis of T1w/T2w ratio mapping confirms the presence of cortical damage in MS and shows a variable expression of intracortical damage according to the disease phenotype. Although in the relapsing-remitting stage, only the subpial layer appears susceptible to damage, in progressive patients, widespread cortical abnormalities can be observed, not only, as described before, with regard to myelin/iron concentration but, possibly, to other microstructural features

First results of a study of TeV emission from GRBs in Milagrito

Milagrito, a detector sensitive to γ-rays at TeV energies, monitored the northern sky during the period February 1997 through May 1998. With a large field of view and high duty cycle, this instrument was used to perform a search for TeV counterparts to γ-ray bursts. Within the Milagrito field of view 54 γ-ray bursts at keV energies were observed by the Burst And Transient Satellite Experiment (BATSE) aboard the Compton Gamma-Ray Observatory. This paper describes the results of a preliminary analysis to search for TeV emission correlated with BATSE detected bursts. Milagrito detected an excess of events coincident both spatially and temporally with GRB 970417a, with chance probability 2.8×10−5 within the BATSE error radius. No other significant correlations were detected. Since 54 bursts were examined the chance probability of observing an excess with this significance in any of these bursts is 1.5×10−3. The statistical aspects and physical implications of this result are discussed

Milagro: A TeV observatory for gamma-ray bursts

Observation of prompt TeV γ-rays from GRBs requires a new type of detector to overcome the low duty factor and small field of view of current TeV observatories. Milagro is such a new type of very high energy (\u3e a few 100 GeV) gamma-ray observatory, which has a large field of view of \u3e1 steradian and 24 hours/day operation. Milagrito, a prototype for Milagro, was operated from February 1997 to May 1998. During the summer of 1998, Milagrito was dismantled and Milagro was built. Both detectors use a 80 m×60 m×8 m pond of water in which a 3 m×3 m grid of photomultiplier tubes detects the Cherenkov light produced in the water by the relativistic particles in extensive air showers. Milagrito was smaller and had only one layer of photomultipliers, but allowed the technique to be tested. Milagrito observations of the Moon’s shadow and Mrk 501 are consistent with the Monte Carlo prediction of the telescope’s parameters, such as effective area and angular resolution. Milagro will have improved flux sensitivity over Milagrito due to larger effective area, better angular resolution and cosmic-ray background rejection

Milagro: A TeV gamma-ray monitor of the Northern Hemisphere Sky

A new type of very high energy (\u3e a few 100 GeV) gamma-ray observatory, Milagro, has been built with a large field of view of \u3e1 steradian and nearly 24 hours/day operation. Milagrito, a prototype for Milagro, was operated from February 1997 to May 1998. During the summer of 1998, Milagrito was dismantled and Milagro was built. Both detectors use a 80 m×60 m×8 mpond of water in which a 3 m×3 m grid of photomultiplier tubes detects the Cherenkov light produced in the water by the relativistic particles in extensive air showers. Milagrito was smaller and had only one layer of photomultipliers, but allowed the technique to be tested. Milagrito observations of the Moon’s shadow and Mrk 501 are consistent with the Monte Carlo prediction of the telescopes parameters, such as effective area and angular resolution. Milagro is larger and consists of two layers of photomultiplier tubes. The bottom layer detects penetrating particles that are used to reject the background of cosmic-ray initiated showers

The Intrinsic Origin of Spin Echoes in Dipolar Solids Generated by Strong Pi Pulses

In spectroscopy, it is conventional to treat pulses much stronger than the linewidth as delta-functions. In NMR, this assumption leads to the prediction that pi pulses do not refocus the dipolar coupling. However, NMR spin echo measurements in dipolar solids defy these conventional expectations when more than one pi pulse is used. Observed effects include a long tail in the CPMG echo train for short delays between pi pulses, an even-odd asymmetry in the echo amplitudes for long delays, an unusual fingerprint pattern for intermediate delays, and a strong sensitivity to pi-pulse phase. Experiments that set limits on possible extrinsic causes for the phenomena are reported. We find that the action of the system's internal Hamiltonian during any real pulse is sufficient to cause the effects. Exact numerical calculations, combined with average Hamiltonian theory, identify novel terms that are sensitive to parameters such as pulse phase, dipolar coupling, and system size. Visualization of the entire density matrix shows a unique flow of quantum coherence from non-observable to observable channels when applying repeated pi pulses.Comment: 24 pages, 27 figures. Revised from helpful referee comments. Added new Table IV, new paragraphs on pages 3 and 1

The Milagro gamma-ray observatory

The Milagro water Cherenkov detector began full operation in January 2000. This detector is capable of monitoring the Northern sky at energies above 500 GeV for sources of equivalent strength to the Crab Nebula over one year of integration. We report on the current performance and sensitivity of Milagro